Resveratrol was just made famous on the Joe Rogan podcast when he hosted Dr. David Sinclair!

Dr. Sinclair PhD extensively studies anti aging and longevity.

 Dr. Sinclair is the author of the new book-Why We Age and Why We Don’t have to.

Dr. Sinclair states that resveratrol can silence expression of certain genes related to aging in our bodies Sirtuin (SIRT1) system. He also thinks resveratrol can help with graying of the hair 

Resveratrol is a compound that some plants produce to fight off bacteria and fungi, and to protect against ultraviolet (UV) irradiation.The resveratrol in wine comes from the skins of red grapes. Blueberries, cranberries, and peanuts are also sources of resveratrol.

Before you go chug a whole a bottle wine to get the benefits, just know that that the average of amount of resveratrol in a bottle can range anywhere from 1.98 to 7.13. 

A typical supplement will have 100mg or more.

Dr. Sinclair has also proposed a new Correct Theory of Aging…

• The old theory stated that we age because we lose DNA/it’s damaged
• David has a new proposal:
  • We age because our DNA gets modified and our cells lose the ability to read it the way they used to

Antioxidants & Resveratrol (notes from Joe Rogan Podcast)

• “Antioxidants have been the biggest disappointment in the aging field… Antioxidants have, with very few exceptions, failed to extend the lifespan of any organism.”
• That being said, Dr Sinclair still supplements with resveratrol
  • Resveratrol is a mild antioxidant – “But the way it really works is it stimulates the body’s defenses against aging and disease”
    • How? – It binds to sirtuins which, as mentioned, are sort of like the body’s defenders 
  • David mixes his resveratrol with yogurt every morning – he takes ~0.5 grams
    • Why yogurt? – It’s important to take the resveratrol with fat to increase absorption
      • In David’s studies (in both humans and mice), if resveratrol was not given with fat, absorption was 5-fold less
      • David makes the yogurt himself out of whole milk 
• David has found that treating mice with resveratrol makes them resistant to the negative side effects associated with eating a high-fat/Western diet
  • What dose? – A human equivalent of 250 mg/day

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Interested in learning more? Listen to the Joe Rogan Podcast with  David Sinclair, Ph.D. – The Joe Rogan Experience #1349